Santana also told the magazine about the pain of recently going through a divorce from his wife of 34 years, Deborah.
The 61-year-old rocker described in the interview how his faith has helped him get through low points in his life, and that he would like to start a church in Maui, Hawaii.
"I’m going to stop playing when I’m 67 and work on what I really want to do, which is to be a minister, like Little Richard," he said to Rolling Stone.
"I’m not sick of what I do, but I find that God gave me the gift of communication even without my guitar and with the ability to get people unstuck with certain sections of the Bible having to do with guilt, shame, judgment and fear."
Santana started his "Live Your Light" tour on September 6 in Auburn, Washington. The 23-date tour ends on October 12 in Concord, California.
His two-disc album "Multi-Dimensional Warrior," a compilation of Santana songs from his 40-year career, comes out on October 14.