FIFA said Blatter would spend four days in the country from September 14-17 "to get a first-hand impression of the progress of the preparations for next year’s Confederations Cup and the 2010 World Cup".
He will also hold talks with South African president Thabo Mbeki, Jacob Zuma, president of the ruling African National Congress (ANC), and regional government officials.
South Africa’s preparations for the World Cup have come under frequent scrutiny with the readiness of stadiums, infrastructure and security issues among the main concerns.
FIFA and local organisers said last month that preparations and stadium construction were on schedule.
During Euro 2008, Blatter told Austrian television that FIFA had contingency plans in place should South Africa be unable to stage the sport’s biggest event.
He later said, however, that only a natural disaster would prevent the country from doing so.